What is DotDr and how can we test it without uploading patient data?

DotDr (Pty) Ltd is a South African biomedical AI engineering studio led by Duncan Luke (duncan@dotdr.co.za) that acts as the switchboard between scientific disciplines. We provide 4 working products and in-house Africa-first vaccine, enzyme, and genetics report demos that laboratories can inspect and test immediately in the browser with zero data upload required.

How does DotDr compare to R3,600+ overseas bioinformatic analysis or Cape Town CHPC queues?

South African labs often pay R3,600+ per sample to send post-sequencing data overseas for bioinformatic interpretation or wait days in Cape Town CHPC supercomputer queues. DotDr runs automated pipelines on our Johannesburg (GCP africa-south1) + Netherlands Google Cloud GPU cluster for ~R250 per run with 42-second genetics report turnaround.

Why is validating foundation AI models on African genomes critical?

Existing global genomic AI models are trained predominantly on European genomes, leaving up to 74% of African Variants of Uncertain Significance (VUS) unresolved. DotDr empowers South African laboratories and biobanks to validate and fine-tune models like AlphaGenome across the 98.5% non-coding regulatory DNA of African genomes for Africa-first drug discovery, vaccines, and diagnostics.

What are DotDr's standardized commercial pricing tiers?

DotDr operates on a transparent 4-tier commercial model: (1) 30-Day Anonymized Pilot Trial at R35,000 ZAR (100% credited toward Sprint 1 upon conversion within 30 days), (2) Custom AI Production Sprints at R160,000 ZAR per 2-week sprint with 100% IP ownership, (3) High-Performance Compute Orchestration in GCP africa-south1 at cost + 15% (~R250/run), and (4) Managed Orchestration & SLA Retainers at R45,000–R120,000 ZAR/month (Standard tier: R65,000/mo).

Google Cloud Johannesburg (africa-south1) + Netherlands GPU Cluster

The AI Switchboard Between Scientific Disciplines

Turnkey orchestration of Google DeepMind & frontier bio-AI models (Gemma 4, AlphaGenome, AlphaFold 3, ESM3, Evo 2, Botanic1) for South African genetics laboratories, pathology networks, and research biobanks.

Request 30-Day Pilot / Pricing Blueprint ↓ Open 1-Page Order Portal & R5,000 Voucher →

~R250 / run

On-demand JHB + NL Google Cloud GPU vs. R3,600+ overseas analysis & CHPC queues

42 Seconds

Automated 2-Page Genetics Report PDF + LIMS JSON for HPCSA sign-off

18s & 1 µL

Laminar-flow vision QC catching benchtop reagent rest & pipetting drift live

98.5% DNA

Africa-First validation across non-coding regulatory DNA & local POC enzymes

Section 01 • Zero Data Upload Required

4 Working Products & In-House Research Demos You Can Use Right Now

Click any product tab below to inspect live telemetry & deliverables

1. The Scientific Switchboard & Automated Genetics Report Engine

Replaces R3,600+ per sample overseas post-sequencing bioinformatic interpretation and multi-day queues on the Cape Town CHPC supercomputer with a ~R250/run automated workflow on our Johannesburg + Netherlands Google Cloud GPU cluster. Scores the 98.5% non-coding regulatory DNA across African genomes and outputs a 2-Page Genetics PDF in 42 seconds.

Request Pilot on This Product ↓ Redeem R5,000 Voucher (20 Free Runs) →

[PRODUCT 01 // SCIENTIFIC SWITCHBOARD & AUTOMATED GENETICS REPORT ENGINE]

> Compute Node: GCP Johannesburg (africa-south1) + Netherlands (europe-west4) GPU Cluster — ~R250 / run (vs. R3,600+ overseas post-sequencing analysis or waiting days in Cape Town CHPC queues)

> Input Token (Zero PII): chr19:40991369:C>T (African-enriched deep intronic variant in 98.5% non-coding regulatory DNA) + CYP2D6 *17/*29

> AlphaGenome AVI Score: 0.94 (Pathogenic Cryptic Splice Donor Gain, +81% retention) • Reclassified from European-biased VUS

> Output Artifact: Draft 2-Page Genetics PDF generated in 42.1 seconds with ACMG PM2/PP3/PS3 evidence + CPIC Tamoxifen dosing alert for HPCSA geneticist sign-off.

Institutional Briefing Decks & Order Portal: 1-Page Product Examples & 2026 Order Form → Wits / NHLS Briefing Deck → SANBI / UWC Biodiversity Deck → Investor & R0.5Bn ARR Thesis Deck →

Section 02 • Scientific Positioning

Why South African Labs Partner With DotDr

We engineer the AI switchboard; your pathologists & geneticists retain 100% clinical authority

01 • AFRICA-FIRST GENOMES

Validating Models on African DNA (98.5% Non-Coding)

Existing global AI models were trained predominantly on European genomes, leaving 74% of African VUS unresolved. We help South African labs validate and train foundation models on African genomes for Africa-first drug discovery, vaccines, and diagnostics.

02 • SOVEREIGN CLOUD SPEED

~R250/Run Cloud vs. R3,600+ Overseas & CHPC Queues

Instead of paying R3,600+ per sample to send post-sequencing data overseas for bioinformatic interpretation or waiting days in Cape Town CHPC supercomputer queues, labs run automated pipelines on our Johannesburg + Netherlands Google Cloud GPU cluster for ~R250 per run.

03 • BENCH TO BIOINFORMATICS

Wet-Lab Reproducibility & Local POC Enzymes

From Gemma 4 Vision catching an 18-second reagent rest difference or 1 µL pipetting variance inside laminar-flow hoods, to ESM3 designing new enzymes for local Point-of-Care (POC) diagnostic tests and Evo 2 flagging TB antibiotic resistance in seconds.

Section 03 • Transparent ZAR Pricing & Onboarding

Standardized 4-Tier Pricing & Pilot Request Form

Zero arbitrary hourly billing • 100% client source code & IP ownership

1. 30-Day Anonymized Pilot Trial (POC)

Fixed-scope benchmark on 20–50 historical test coordinates (anonymized chr:pos:ref>alt). 100% credited toward Sprint 1 if converted within 30 days.

R35,000 ZAR100% Credited

2. Custom AI Production Sprints

Fixed-price 2-week custom sprint: full-stack integration into your LIMS, custom genetics report agents, and 100% IP ownership (monthly 3rd-party hosting pass-through).

R160,000 ZARPer 2-Week Sprint

3. High-Performance Compute Orchestration

Dedicated GPU clusters in GCP africa-south1 (Johannesburg) + Netherlands burst nodes. Replaces R3,600+ overseas analysis & CHPC queues.

Cost + 15%~R250 / GPU Run

4. Managed Orchestration & 99.9% SLA

Post-deployment retainers from R45,000 – R120,000 ZAR/month including monthly model tuning and ACMG/CPIC rule updates.

R65,000 ZAR/ Month Standard

Main Call to Action • Direct to Duncan Luke

Start Your 30-Day Pilot or Request Blueprint

Your Full Name & Title *

Institution / Laboratory *

Institutional Work Email *

Primary Product or Pilot Focus

✓ Request Confirmed & Prepared

Thank you, . Your blueprint and pilot onboarding dossier for is ready to send to duncan@dotdr.co.za.

Section 04 • Regulatory Safeguards & FAQ

POPIA Act 4 Compliance, HPCSA Guardrails & FAQ

Executive Lead: Duncan Luke (duncan@dotdr.co.za)

POPIA Zero-PII Policy Never stores patient names, IDs, or hospital numbers. Ingests only pseudonymous coordinates (chr:pos:ref>alt).

HPCSA Assistive Copilot HPCSA-registered pathologists and medical geneticists retain 100% final diagnostic authority on all genetics reports.

Sovereign Cloud + Burst Primary data residency in GCP Johannesburg (africa-south1) + authorized non-PII Netherlands GPU burst.

ISO 15189 Audit Trail Every AVI score, AlphaFold 3 metric, and 18-second laminar-flow timestamp is cryptographically logged.

Can we test DotDr's products right now without uploading patient data?

Yes. All 4 core products are live right now in Section 01 above and on our 1-Page Order Portal using synthetic/anonymized coordinates with zero data upload required.

How does DotDr eliminate R3,600+ overseas fees and Cape Town CHPC queues?

Instead of paying R3,600+ per sample for overseas post-sequencing bioinformatics or waiting days in shared Cape Town CHPC queues, DotDr runs on our dedicated Johannesburg + Netherlands Google Cloud GPU cluster for ~R250 per run (generating a 2-Page Genetics PDF in 42 seconds).

Why validate foundation AI models on African genomes (98.5% non-coding DNA)?

Global models are trained predominantly on European genomes, leaving up to 74% of African VUS unresolved. DotDr helps South African partners validate and train models on African genomes—powering Africa-first diagnostics, vaccines, and drug discovery.

How does DotDr enforce wet-lab reproducibility and design local POC enzymes?

Gemma 4 Vision monitors laminar-flow hoods to catch an 18-second reagent rest difference or 1 µL pipetting variance live, while ESM3 designs new enzymes for local Point-of-Care (POC) diagnostic tests and Evo 2 flags TB antibiotic resistance in seconds.